Vinblastine is a drug used in the treatment of different types of cancer including Hodgkin's lymphoma, bladder cancer, brain cancer and testicular cancer. There are structures inside cells called microtubules which act as the architecture of cells with Vinblastine working by disrupting this architecture. Likely side effects include hair loss, hypertension, excess sweating and muscle cramps.
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Vinblastine belongs to a group of medicines known as vina alkaloids. Derived by plants, this class of drugs are used in the treatment of a wide variety of cancers. Vinblastine is used in the treatment of, for example, Hodgkin's lymphoma, brain cancer, bladder cancer, and testicular cancer. Vinblastine may also be used for purposes not mentioned here, as determined by your oncologist. Vinblastine is used to inhibit mitosis from occurring in cells, with mitosis being another name for cell division. Vinblastine does not, however, discriminate against cells it targets and, as a consequence, the drug can damage both healthy and cancerous cells. This is why hair loss remains a potential side-effect in patients taking this medicine.
- hodgkin's lymphoma
- brain cancer
- bladder cancer
- testicular cancer
- Kaposi's Sarcoma
The following doses with respect to Vinblastine are not fixed. Each dose is dependent upon a number of factors, not least whether the patient has any additional complicating factors such as age, co-administration of interacting drugs, or the presence of additional disease. With this in mind, the following doses should be considered typical all else being equal. In each case below, the manufacturer recommends doses to be increased incrementally over time. The manufacturer also recommends no more than one dose is to be administered each week (with the exception where one dose is given as divided doses).
- Breast Cancer Adult Dose: 3.7mg/m2 to be administered intravenously over one minute. This may rise to a maximum of 18.5mg/m2.
- Kaposi's Sarcoma Adult Dose: 3.7mg/m2 to be administered intravenously over one minute. This may rise to a maximum of 18.5mg/m2.
- Testicular Cancer Adult Dose: 3.7mg/m2 to be administered intravenously over one minute. This may rise to a maximum of 18.5mg/m2.
- Hodgkin's disease Adult Dose: 3.7mg/m2 to be administered intravenously over one minute. This may rise to a maximum of 18.5mg/m2.
- Lymphoma Adult Dose: 3.7mg/m2 to be administered intravenously over one minute. This may rise to a maximum of 18.5mg/m2.
Vinblastine Side Effects
As Vinblastine is a chemotherapeutic agent, patients can expect to experience at least some side-effects. Some patients will experience more side-effects than others, and this will depend on the nature of their age, use of concomitant medications and general health. The list of side-effects below is not intended to be an exhaustive list but, instead, focuses on the most common side-effects experienced by patients taking Vinblastine.
Common side-effects include:
Consult your healthcare provider should you experience any of the following symptoms:
- Blood in Urine
- Red Spots on Skin
Vinblastine is a chemotherapeutic drug and, consequently, it carries with it the risk of severe drug interactions. These interactions will be considered by your oncologist and pharmacist, both of which will place your best interests at the center of their consideration. If you are concerned about the nature of any given interaction, you should consult these concerns with your healthcare provider. Drugs that interact with Vinblastine include: