VEGF Antibodies Drug Class

The Vascular Endothelial Growth Factor or VEGF antibodies treat cancers by slowing down the growth of cancer cells and prevent them from spreading. They stop the development of new blood vessels (or angiogenesis) by the tumors. Tumors develop new blood vessels in order to aid them in receiving nutrients required to survive. VEGF is a cytokine, the substance certain immune system cells secrete, affecting other cells, in the proper formation of blood vessels, as well as the development of tissues that undergo abnormal angiogenesis. It promotes angiogenesis and raises capillary blood vessel permeability. VEGF combines with some cells to trigger the formation of new blood vessels. The growth of tumor blood vessels could be slowed down or stalled by interfering with their development, and that what VEGF antibodies do. VEGF antibodies are vital additions to cancer treatment. Many VEGF antibodies are being tested as adjuvant, maintenance or with other medications to treat cancer, and hopefully give better outcomes in patients.

VEGF Antibodies Drugs

These medications can only be prescribed by a physician. Some of the most common VEGF antibodies include:

VEGF Antibodies Uses

VEGF antibodies are used to treat breast, colon, ovarian, cervical, renal, thyroid and lung cancers, as well as macular degeneration, glioblastoma, vitreomacular adhesion and brain tumors.

Angiogenesis is pointed as a forerunner of tumorigenesis, which may lead to the progression of tumor and metastasis. VEGF antibodies stop angiogenesis to prevent or treat cancer. They are even used as treatment of certain cancers that have already spread to other body parts (metastasis). Studies show that the antibody raises the survival level of a metastatic colon cancer patient by five months when used as treatment with chemotherapy. They are taken by the body through injection every two weeks, along with chemotherapy.

VEGF Antibodies Side Effects

VEGF antibody decreases the wounds’ ability to heal. Thus, it is not advisable to be used shortly after a surgery. VEGF antibodies side effects can vary from the most common ones to the serious side effects that need immediate medical attention. The following are the most common side effects:

  • Diarrhea
  • Headache
  • Runny nose
  • Watery or dry eyes
  • Flaky or dry skin
  • Nosebleed
  • Rectal bleeding
  • High blood pressure
  • Weakness and fatigue
  • Back pain
  • Fatigue
  • Loss of appetite

Serious side effects include:

  • Heart failure
  • Holes in the colon that need repair through surgery
  • Kidney damage brought by the more protein in the urine Decreased the ability to heal wounds
  • Blood clotting or bleeding
  • Fainting, seizures, blackout or convulsions
  • Ovarian failure

VEGF Antibodies Interactions

Under the medication of VEGF antibody may prompt the patient to be more cautious. Since there are numerous types of over-the-counter drugs, prescriptions, herbal products and vitamins which could react with the VEGF antibody, it is vital for patients to tell their health professionals the medicines they are currently taking, those they started taking or have stopped using.

For example, use of VEGF antibody was reported as among the reasons for the death of bone tissue (osteonecrosis) of the jaw. The risk of jaw osteonecrosis increases with exposure to other factors such as dental disease.