Trifluridine is a prescription drug that is used in the treatment of viral infections (herpes simplex virus) of the eye (inflammation of the cornea and conjunctiva). Trifluridine belongs to the antiviral agents group of medications and works by stopping the growth of the herpes simplex virus. Trifluridine fights eye infections that result from some viruses (the herpes simplex virus).
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Trifluridine is used in the treatment of herpes infection of the eye. Herpes is a virus that quietly lives in the body until its outbreak is triggered. Trifluridine does not cure the infection, however, treating an outbreak is important to fasten the healing of the swelling/sores in the eye in order to reduce the risk of complications (for example, vision loss). Trifluridine works by blocking the growth of type 1 and 2 herpes simplex virus. The herpes simplex virus can cause swelling or ulcers in the cornea or eyelids. Trifluridine can fight eye infections that are caused by other viruses.
- Herpes simplex virus (eye)
Trifluridine comes in the form of an eye drop solution. Patients should first wash their hands before applying Trifluridine in order to avoid contamination. The patient should place the dropper above the eye and place the drop into the pouch created after pulling down the eyelid.
- Patients should instill a single drop of Trifluridine ophthalmic solution, 1% on the cornea of the affected eye after every 2 hours. The maximum daily dose should not exceed 9 drops for a period of 24 hours, until complete re-epithelialization of the corneal ulcer. After re-epithelialization, it is recommended to treat an extra 7 days with a single drop every 4 hours with a minimum daily dose of 5 drops.
- Incase no improvement is noted after 7 days or there is no complete re-epithelialization after 14 days, the patient should consider other forms of treatment because continued use of Trifluridine for more than 21 days can lead to ocular toxicity
- In case a patient is using other eye medication (ointments or drops), then such a patient should wait at least 5-10 minutes before applying Trifluridine
Trifluridine Side Effects
Trifluridine can cause some side effects; therefore, patients should be wary of side effects that become persistent or worsen. Common Trifluridine side effects
- Blurred vision
- Stinging, burning, redness, itching, mild eye pain
- Feeling pressure inside the eyes
Serious Trifluridine side effects
- Tunnel vision
- Irritation, burning, severe pain in the eyes
- Severe swelling around the eyes
- A very serious allergic reaction
Drug interactions can change how trifluridine works or increase the risk for serious side effects. Patients should inform their doctors about the use of other drugs while using Trifluridine in order to avoid the possibility of any drug interaction. Trifluridine has not recorded any interaction with other medications that are injected or taken orally. However, patients should be wary of other eye medications (ointments or drops). It is important for the patient to inform the doctor about the use of other eye medications in order to avoid the possibility of any interaction.
- No known interactions with Trifluridine