Soliris is medicine used by physicians to treat a certain type of blood disease. Soliris medicine is a humanized monoclonal antibody that provides approved therapy for treatment of the said blood condition. The generic name for Soliris is Eculizumab. Solirisis approved by the FDA for the treatment ofvarious other diseases and is under investigations as a possible drug for treatment of other rare conditions.
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Soliris is used to treat the blood disease known as paroxysmal nocturnal hemoglobin or PNH. Soliris is also prescribed for the treatment of serious kidney disorder known as Atypical hemolytic uremic syndrome (aHUS). Soliris works by binding itself to proteins in the blood that can destroy the red blood cells in patients born with a certain genetic condition. Soliris prevents the breakdown of red blood cells in patients suffering PNH. In some cases, physicians may prescribe the use of Soliris to treat conditions not mentioned here.
Soliris dosage prescribed by the doctor will depend on certain factors such as the condition being treated. It is important that any physician who prescribed Soliris to enroll in Soliris REMS. Given ACIP guidelines should be strictly adhered to by the doctor in order to reduce the risks of serious infections. The recommended Soliris dosage for the treatment of PNH is as follows:
- 600 mg per week for the first 4 weeks
- 900 mg for the fifth dose given a week later
- 900 mg after every fortnight thereafter
The recommended Soliris dosage for the treatment of aHUS is as follows:
- 900 mg per week for the initial 4 weeks of treatment
- 1200 mg for the 5th dose which is administered a week later
- 1200 mg every 2 weeks thereafter
Patients should ensure to take Soliris medication exactly as advised by their doctor. Any questions can be directed to the physician.
Soliris Side Effects
There are a number of possible Soliris side effects even though most patients on Soliris experience few or no side effects. A doctor who prescribes Soliris understands its benefits to the patient and will monitor them for any possible side effects. There could be some unknown Soliris side effects and patients are advised to report these. Some of the known Soliris side effects include:
- Back pain
- black tarry stools
- Bladder pain
- blurred vision
- Chest pain
- cloudy or bloody urine
- Burning or stinging sensation on skin
- Muscle pain
Some Soliris side effects may not need medical attention and they will subside once the body gets used to the medication. However, any serious Soliris side effects and allergic reactions should be reported to the doctor at once for immediate attention. Any mild Soliris side effects that do not go away should be reported to the doctor after about 1 week.
Drug interactions affect the way a drug works and will increase chances of serious side effects. It is important for patients to keep a list of the medicines, prescription, non-prescription and herbal medicine they are currently using as well as any other products such as supplements. This list can be shared with the doctor in order to check for any possible Soliris interactions. There are 2 products known to interact mildly with Soliris:
However, it is possible that other drugs or products could have a serious Soliris interaction so patients should check with the pharmacist or prescribing doctor.