Brand Name(s): Rhophylac
Drug Class: Immunoglobulin
Treats: Blood disorders in pregnancy, immune thrombocytopenia purpura
Rh immunoglobulin is a drug used as a prophylaxis against blood disorders during pregnancy or blood transfusions. It may also be used in the treatment of specific blood disorders, such as immune thrombocytopenia purpura (ITP). Common side effects associated with Rh immunoglobulin use include chills, headache, and injection site reactions.
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Rh immunoglobulin Uses
Rh immunoglobulin is a drug used in the treatment of blood disorders associated with pregnancy and blood transfusions. It is administered to the patient via the intramuscular route.
Rh immunoglobulin may also be used in the treatment of specific blood disorders such as immune thrombocytopenia purpura (ITP). Rh immunoglobulin may also be used for purposes not listed in this guide, at the discretion of the prescriber.
Rh immunoglobulin is used in the treatment of the following conditions:
- Prophylaxis against blood disorders in pregnancy
- Immune thrombocytopenia purpura (ITP)
Rh immunoglobulin Dosage
The dosage of Rh immunoglobulin depends on the needs of the patient, and the extent of their pain severity. The dose also depends on whether the patient is taking any additional medications or has an underlying illness.
- Adult Dose: 300mcg to be administered IM at gestational week 26-28, or within 72 hours of delivering a Rho (D) positive baby.
Immune thrombocytopenia purpura
- Adult Dose: 50mcg/kg to be administered IV as 2mL per 15/60 seconds.
Rh immunoglobulin Side Effects
Like any other drug, Rh immunoglobulin may cause side effects. Patients experiencing severe side effects - including those not listed below - should discontinue the medicine and seek further professional advice. Patients must also be aware that the side effects listed below are not intended to be an exhaustive list.
Common side-effects with Rh immunoglobulin include:
- Mild fever
- Mild pain
- Injection site reactions
Patients may experience severe side effects, including:
- Chest pain
- Blood in urine
- Shortness of breath
- Yellowing skin/eyes
Rh immunoglobulin Interactions
As with many drugs, Rh immunoglobulin is associated with its own range of potential drug interactions. These interactions not only occur with prescription medication but may also occur with over-the-counter formulations - such as herbal remedies and supplements. Patients should inform their doctor of any medication they are currently taking. The list of drug interactions below is not intended to be exhaustive. Patients should consult their doctor or pharmacist if they are concerned about any potential drug interaction.
Common drug interactions with Rh immunoglobulin include:
- Smallpox vaccine
- Measles vaccine
- Influenza virus vaccine
- Rotavirus vaccine
- Typhoid vaccine
- Yellow fever vaccine