Generic Name(s): pralidoxime
Drug Class: Antidotes
Treats: Nerve Agent Poisoning, Organophosphate Poisoning, Anticholinesterase Overdose
Protopam Chloride (pralidoxime) is a medicine that is widely used in the treatment of the poisoning by pesticide or any other chemical. It reverses muscle paralysis and weakness caused by a poison like nerve gas. It is available as a solution and should be administered as an injection either IV or IM.
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Protopam Chloride Uses
Protopam Chloride treats a broad range of poisoning conditions. It can be used as an antidote to treat poisoning case by either chemical or pesticide. Protopam Chloride can also be used to neutralize the effect of severe drug overdose. Protopam Chloride works by reducing the effect of the chemical that is responsible causing severe health complications. It treats muscle disorders by reversing muscle weakness or any paralysis caused by the chemical. Protopam Chloride may also be used as a treatment for other conditions as the physician may prescribe.
Below you will find Protopam Chloride uses:
- Nerve Agent Poisoning
- Organophosphate poisoning
- Anticholinesterase overdose
Protopam Chloride Dosage
Protopam Chloride dosage must be observed as per the physician's prescription. Like many other drugs, it is packaged with clear administration instructions from the manufacturer. If there is no clear Protopam Chloride manufacturer's instructions go for a certified physician to determine the right dosage. Do not try to determine your own dosage as this can cause severe damage if the dosage inaccurate. Protopam Chloride is a solution and it should be for administration as an injection through the intravenous or intramuscular route only.
Adult Protopam Chloride dosage:
- IV: 1 to 2 g as an IV infusion over 15 to 30 minutes as the initial dose.
- Second dose: 1 to 2 g may be administered after 1 hour if muscle weakness has not been relieved after the initial dose.
- IM; 600 mg IM and a second dosage of the same if the symptoms persist after 15 minutes past the initial dose.
Pediatric Protopam Chloride dosage:
- IV: 20 to 50 mg as an IV infusion over 15 to 30 minutes as the initial dose.
- Second dose: 10 to 20 mg may be administered after 1 hour if muscle weakness has not been relieved after the initial dose.
- IM: 15 mg/kg IM and a second dosage of the same if the symptoms persist after 15 minutes past the initial dose.
Protopam Chloride Side Effects
Protopam Chloride may cause unexpected side effects to the patient. It is, therefore, important for patients to inform their doctor about anything unusual after taking Protopam Chloride. However, common side effects do not cause any health complications, so there is no need to report them. Patients should avoid an overdose of Protopam Chloride since it can cause severe complications. Below you will find a list of Protopam Chloride side effects. Note that not all possible Protopam Chloride side effects are listed.
Common side effects:
- Tightness in the chest
- Swelling of the mouth
- Fast heartbeat
Severe side effects:
- Difficulty urinating
- Difficulty breathing
- Trouble sleeping
- Severe dizziness
- Vision changes
Protopam Chloride Interactions
Many drugs have a tendency to interact with other substances. The interaction of the drugs may cause side effects ranging from mild to severe ones. Protopam Chloride is among the drugs that are known for possible interactions. Avoid combining Protopam Chloride with other drugs unless your physician has advised you to do so. This will reduce significantly the chances of severe interactions.
Below you will find a list of Protopam Chloride drug interactions. Note that not all possible Protopam Chloride interactions are listed.
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