Generic Name(s): promethazine
Drug Class: Antihistamines
Treats: morning sickness, hyperemesis gravidarum, restlessness, agitation, nervousness, migraines,
Phenoject-50 is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. Phenoject-50 has strong sedative and weak antipsychotic effects. Phenoject-50 also reduces motion sickness and has antiemetic and anticholinergic properties. It is prescribed for insomnia when benzodiazepines are contraindicated in some countries.
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Insomnia is a sleep disorder whereby there is an inability to stay asleep or fall asleep as long as one may desire. Insomnia is most often thought of as both a medical symptom and a sign that can accompany several psychiatric and medical disorders which are characterized by a persistent difficulty falling asleep, staying asleep or sleep of poor quality. Insomnia is particularly common in the elderly but can occur at any age. Insomnia can be either long or short term; it can lead to depression, memory problems, an increased risk of heart disease, irritability and automobile related accidents.
Uses of Phenoject-50
- As a sedative.
- For preoperative sedation and to counteract post narcotic nausea.
- To reduce restlessness, agitation and nervousness caused by psychiatric conditions.
- As anti-allergic medication to combat hay fever or to treat allergic reactions.
- Together with codeine or dextromethorphan against a cough.
- As a motion sickness or sea sickness remedy when used with ephedrine or pseudoephedrine.
- Used in the treatment of migraines.
- To combat moderate to severe hyperemesis gravidarum and morning sickness.
Follow directions on the label or take your Phenoject-50 dosage as your doctor prescribes. Do not use in smaller or larger amounts for longer periods than recommended. Since Phenoject-50 is taken when needed, you may not be on a dosing schedule. Because Phenoject-50 is an injected medication, your doctor or a health professional will administer your dosage for you. Below you will find a typical dosage of Phenoject-50.
For parental dosage forms only
- Deep intramuscular injection is the preferred route of administration. ;Although intravenous administration is well tolerated, Phenoject-50 should not be administered at a rate in excess of 25 mg per minute and in concentrations of more than 25 mg per ml. Rapid intravenous administration of Phenoject-50 may produce a transient fall in blood pressure.;
The intra-arterial administration is not recommended because of the possibility of severe artery spasm and resultant gangrene; also, subcutaneous administration is not recommended, since chemical irritation and necrotic lesions have been noted on rare occasions.
Phenoject-50 Side Effects
Phenoject-50 has some side effects just like any other drug. Depending on the body"s ability to handle the effects of the drug, the severity of these side effects may vary from one person to the other. These side effects may not be experienced at all with some people. Note that this list does not include all side effects
Common side effects:
- Confusion in the elderly
- Dry mouth
- Chest discomfort
- Short temper
Severe side effects include:
- Neuroleptic malignant syndrome.
Because of the potential for more severe side effects, the elderly should avoid this drug. In many countries, Phenoject-50 is contraindicated in children less than two years of age due to problems with respiratory depression and sleep apnea.
Some drugs and substances may interact with Phenoject-50 and cause severe side effects to your body or may reduce the drug"s effectiveness. In most cases, Phenoject-50 is taken with other drugs unless the doctor authorizes so. Thus, do not or change, stop or start the use of any medication without informing your doctor. Using Phenoject-50 with the following medicines is not recommended in some cases but may be required.
Moderate interactions of Phenoject-50 injection. These medications may result;in less risk when taken together:
Severe interactions of Phenoject-50 injection. It"s not advisable to take Phenoject-50 with the drugs below:
Note that it"s very essential to share a list of all prescription, non-prescription drugs and herbal remedies that you may be taking with your doctor in order for him/her to monitor possible interactions on behalf of you.