Brand Name(s): Votrient
Generic Name(s): Pazopanib
Drug Class: kinase inhibitors
Treats: kidney cancer
Pazopanib is a medication belonging to a class of drugs known as tyrosine kinase inhibitors. Pazopanib is used by patients to treat advanced cell carcinoma (kidney cancer). Pazopanib works by interfering with the growth and spread of cancer cells in the body. Pazopanib also works by decreasing blood supply to the cancer tumor thus slowing tumor growth.
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Apart from treating kidney cancer, Pazopanib drug can also be used to treat other type of cancer like the soft tissue sarcoma (a tumor that develops in or around muscles, tendons, joints, organs or blood vessels). Most doctors normally give Pazopanib to patients when other cancer medications have been tried without being successful. Patients are advised to follow the doctor's instructions before taking the medicine. However, the drug is not recommended for children under two years of age as it may cause serious side effects on them. Pazopanib is also not recommended for patients with severe liver disease or those allergic to Pazopanib as this may lead to complications.
- Kidney Cancer
The dosage for Pazopanib will entirely depend on one's medical condition, weight, age and response to treatment. Pazopanib is taken by mouth without food, usually once daily as prescribed by the doctor. Pazopanib tablets should also be swallowed wholly but not crushed, chewed or broken into pieces to avoid the risks of side effects. Patients should also avoid eating grapefruit or drinking grapefruit juice while taking the medicine since this can increase the amount of the medication in the bloodstream. One should see the doctor in case of an overdose or missed dosage for further guidance.
- The recommended starting dose of Pazopanib is 800 mg orally once daily. It is also advisable to take the medicine at least 1 hour before or 2 hours after food.
Pazopanib Side Effects
Pazopanib has different results varying from one individual to another. Remember Pazopanib is a prescription medicine and should be taken regularly without interruption. Sudden stoppage of its administration can be fatal to the user. Some undesired effects are due to the active ingredient which may cause an allergic reaction and may at times require urgent medical attention. Among the common side effects associated with the use of Pazopanib include:
- Abdominal or stomach pain
- Bleeding gums
- Blurred vision
- Clay colored stools
- Decrease appetite
- Hoarseness or husky voice
- Muscle cramps
- Prolonged bleeding from cuts
- Sore throat
- Yellow eyes or skin
- Irregular or slow heartbeat
- Swelling of puffiness of the face
Interactions with Pazopanib can lead to a different functioning of the drug. Interactions can cause severe further adverse side effects which may be unfavorable to the user. There are a number of drugs which can easily combine with Pazopanib to produce different end results. Haldol (haloperidol)-The combination with Pazopanib can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening. One should thus consult the doctor before using the two medicines together. Other common interactions include:
Patients should be careful when using other drugs alongside Pazopanib. It is however recommended to inform the doctor of any medicine one is taking before prescribing to Pazopanib in order to avoid complications. In the case of any doubts or severe effects, one should report to the doctor immediately for further treatment.