Lincosamides are a class of antibiotic drugs used in the treatment of numerous infections. They work by interfering with cellular structures called ribosomes. Ribosomes are needed by cells to produce proteins, and lincosamide antibiotics disrupt this process. Lincosamides tend to work best against anaerobic bacteria, but have also proven effective against MRSA and malaria. One of the chief lincosamide antibiotics, clindamycin, is widely tolerated by patients around the world, making it one of the World Health Organization’s most essential medicines.
Lincosamide Antibiotics Drugs
Below you will find a list of drugs that fall under the class of Lincosamide Antibiotics.
Lincosamide Antibiotics Uses
Lincosamides have many uses, ranging from acne and endocarditis to bone infections such as osteomyelitis. Lincosamides are also effective against a range of anaerobic bacteria, while drugs like clindamycin are used as a prophylaxis for patients who may suffer from endocarditis, but who are allergic to penicillin drugs. Below you will find a list of uses for lincosamide antibiotics.
- Toxic shock
- Tooth infections
Lincosamide Antibiotics Side Effects
One of the classic side effects of lincosamide antibiotics, particularly clindamycin, is Clostridium difficile-associated diarrhea. Also known as pseudomembranous colitis, the severity of this condition varies from patient to patient, though most simply experience mild diarrhea. In severe cases, the entire colon can become inflamed which in some cases can be fatal. Other common side effects are listed below.
- Abdominal pain
- Disrupted liver function
- Itching and redness in topical solutions
Lincosamide Antibiotics Interactions
Lincosamide antibiotics interact with a class of drugs known as neuromuscular blocking agents. This class of drugs – which includes succinylcholine, rocuronium, and atracurium – are used with conditions requiring muscle relaxation. Clindamycin augments the effects of neuromuscular blocking drugs, making their effects longer lasting. This can become particularly problematic if the dose is sufficiently high.
LIncosamides should be avoided in patients taking a class of drugs called macrolides. Drugs in this class include azithromycin and erythromycin. Given that both lincosamides and macrolides have a similar mode of action, they may increase resistance in bacteria over the long term.