Leucovorin is considered a form of folic acid and is used to treat cancers. Folic acid helps your body produce and also maintain new cells. Similarly, it helps prevent changes to DNA that may lead to cancer. Folic acid is found in many foods such as peas, spinach, dried beans, oranges and many more.
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Leucovorin is used along with certain other chemotherapy drugs in the treatment of cancer. Leucovorin is used to help 5-fluorouracil (5-FU) work even better in treating colorectal, head and neck, or other cancers. It is also used as a cell-protecting agent. Leucovorin helps protect the normal cells found in the bone marrow and digestive tract from damage from chemotherapy drugs such as methotrexate.
Leucovorin dosage is dependent on the individual that it is being administered to. The following dosage is an average dose and could differ among individuals. Follow your medical professional"s directions for best results.
- The usual adult dosage for Leucovorin is as follows; 200 mg/m2 diluted to 10 mg/100 mL with sterile water for injection, for at least 3 minutes. Followed by 5-FU 370 mg/m2 IV.
- Alternatively you can use leucovorin 20 mg/m2 IV diluted to 10 mg/mL with sterile water for injection. Follow with 5-FU 425 mg/m2 IV.
- Either regimen may be continued daily for five days, and then repeated on a 28-day cycle for two cycles intervals as long as the patient has recovered from toxicity.
Leucovorin Side Effects
In most cases, you will probably not have most of the side effects gin below, but in case you have any of them, talk to your doctor or nurse. They can help you understand the side effects and cope with them. Some of the common side effects associated with Leucovorin are;
- Facial flushing
- Shortness of breath
- Difficulty breathing C
- losing up of the throat
- Swelling of the face, mouth, lips, or tongue
- Tightness in the chest
Like any other drug, Leucovorin may interact with other drugs and substances. You should consult with your doctor or medical professional before adding any new medication, including over the counter drugs. Below is a list of drugs that have been known to interact with Leucovorin. Note that this list does not include all possible drug interactions.
Common medication of drug interactions in combination with Leucovorin are;