Interleukin Antagonists are proteins found in humans that are encoded by the IL1RN gene. Essentially, this is a protein that prevents the Interleukin 1 from sending a signal to that particular cell. The substance is secreted by a number of different types of cells, including immune, epithelial, and adipocytes. It also works to reduce inflammation and inflammatory effects of outside stressors, modulating many of these types of responses. Changes or mutations in this gene have been known to produce additional risks and complications. This includes a higher risk of osteoporotic fractures and even schizophrenia in certain cases (elevated levels have been observed in such patients). For these reasons, the Interleukin Antagonists are often used in the treatment of rheumatoid arthritis, which is considered to be an autoimmune disease.
Interleukin Antagonists Drugs
Below are listed some of the drugs in the Interleukin Antagonists class.
Interleukin Antagonists Uses
Many people initially start their treatment for rheumatoid arthritis with COX-2 inhibitors and even NSAIDs. However, using Interleukin Antagonists is more of an actual treatment, rather than only an attempt to deal with the symptoms. In fact, these medications actually help to decrease the progression of the disease. It works by blocking the biological activity of Interleukin-1 through the inhibition of its binding to the Interleukin receptors found in several tissues and organs.
This helps to stop the pain and inflammation often associated with rheumatoid arthritis. The modification of the activity present in conditions like rheumatoid arthritis give this medication a very promising future. There is also ongoing research into the use of Interleukin Antagonists to help with the treatment and control of diabetes, although this is not the primary role for these compounds.
Interleukin Antagonists Side Effects
There are several potential side effects which may be noticed when using Interleukin Antagonists. The most common of these is injection site reactions, which do occur in nearly two-thirds of patients using the FDA approved daily dosage levels. Reactions are generally mild (including some possible pain, swelling, and redness) and will normally resolve in one to two months.
Another potential side effect is the increase in serious infections. This is especially true when used in combination with a TNF (tumor necrosis factor) inhibitor, like Enbrel. Always speak to your physician when thinking about changing your arthritis treatment in regards to potential side effects since they tend to modify biological activity.
Interleukin Antagonists Interactions
According to the FDA, you should not use Interleukin Antagonists in combination with TNF inhibitors. The most common of these are Enbrel and Remicade. Potential effects of combining these types of medications include neutropenia, which has occurred in approximately 3 percent of cases.