Generic Name(s): Chlorpheniramine, pyrilamine, phenylephrine
Drug Class: Upper respiratory combinations
Treats: Stuffy nose, Watery eyes, Sinus congestion, symptoms of an allergic reactions
Histatan belongs to a group of drugs known as upper respiratory combinations. Histatan is a combination drug that is constituted of the following individual drugs: phenylephrine, pyrilamine, and chlorpheniramine.
Phenylephrine acts primarily as a decongestant that causes vasoconstriction of the blood vessels because blockage of nasal passages is caused by dilated blood vessels. Pyrilamine and chlorpheniramine are antihistamines that aid in treating flu-related symptoms like sneezing and coughing. Therefore, Histatin is used to treat the symptoms caused by flu or common cold and allergies.
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Chlorpheniramine and pyrilamine (mepyramine) are antihistamines and important components of Histatan. They are antihistamines that act by inhibiting the action of a naturally produced chemical substance known as histamine. Histamine is released by the body in the case of an allergic reaction and induces certain effects like sneezing, coughing, and a running nose. Pyrilamine and chlorphenamine act by inhibiting the H1 histamine receptor. They actively bind to these receptors that are located in capillaries, bronchi and smooth muscles.
Phenylephrine acts as an alpha-adrenergic agonist. It mimics the action of epinephrine and binds to the adrenergic receptors causing vasoconstriction. This will decongest the nasal passage. Histatan can be used to treat the following conditions
- Stuffy nose
- Watery eyes
- Sinus congestion
Histatan is a prescription drug, which means that you need to stick to the stipulated dose in order for you to attain the intended results. Histatan is available in two forms; tablet and syrup of which these two forms have different absorption rates.
Histatan can be taken with or without food depending on your doctor's orders. The usual dose for Histatan is set based on a few factors:
- Your prior response to similar medication
- The medical condition being treated
- Your medical history
Therefore, the usual Histatan dose is as follows:
- Adult dose: 5 to 10 ml orally administered every 4 to 6 hours and should not exceed 60 mg within 24 hours. 1 or 2 tablets should be orally administered after 4 to 6 hours a day.
- Pediatric dose: 2-5 years: 2.5 ml orally administered after every 12 hours. 6-12 years; 5ml orally administered every 12 hours. Above 12 years: 5-10 ml orally administered every 12 hours.
Histatan Side Effects
Like any other prescription drug, the use of Histatan is accompanied by some side effects. These side effects occur due to the sudden shift in homeostasis and the body tries to regain its equilibrium. These side effects are much anticipated and you need to consult your doctor who will guide you through every step.
The common side effects are as follows:
- Loss of appetite
- Dry mouth
- Stomach upset
- Trouble sleeping
If the symptoms persist or if you experience the following severe side effects seek immediate medical attention:
- Severe allergic reactions
- Irregular heartbeats
- Blurred vision
- Fever or chills
- Difficulty urinating
Interactions are important to know since they can affect Histatan's mechanism of action and in turn cause very severe side effects. At times, these interactions can cause Histatan's efficacy to reduce or cause the removal of the drug from the system completely even before achieving the desired results. It is important that you tell your doctor what you are taking in order for him/her to advise you on the way forward. These interactions can be over the counter medication or herbal remedies, either way inform your doctor.
Here are Histatan's interactions:
- MAO inhibitors like linezolid
- Topical antihistamines
- Sleep and anxiety medication like diazepam
Histatan can interfere with certain medical tests like the brain scan for Parkinson's disease and the results might be exaggerated.