Generic Name(s): Hepatitis B immune globulin
Drug Class: Immune globulins
Treats: Hepatitis B virus
H-Big (hepatitis B immune globulin) is a special drug that offers protection against hepatitis type B virus. It is a sterile solution made from healthy human plasma and should be administered intravenously. H-Big is typically prescribed to patients that are receiving a liver transplant or babies of mothers infected with type B form of hepatitis.
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H-Big is a medication that is used to boost the body's immunity system, specifically against hepatitis B. It is extracted from human blood and contains the antibodies or helps in the production of antibodies that fight the hepatitis B virus. This is a type of viral infection that is spread through blood and causes fever, debility and jaundice, especially in children. H-Big is prescribed to patients undergoing liver transplant or those exposed to contaminated blood. However, H-Big is not a vaccine and does not provide long-term protection. It can also be used to treat other conditions as prescribed by the physician. Below you will find the uses of H-Big.
- Hepatitis B virus
Dosage of H-Big depends on the individual and the condition being treated. H-Big should be administered intravenously as an injection for it to be effective. Dosage should be determined by the age, body weight and the medical condition of the patient. At the same time, H-Big dosage should be individualized based on the patient's response to the drug and also the severity of the condition. Below you will find a typical dosage of H-Big.
Adult dosage for exposure to hepatitis B virus:
- Liver transplantation: 20,000 intl units IV with the grating of the transplanted liver. This is followed by one week of 20,000 units IV daily.
Pediatric dosage for exposure to hepatitis B virus:
- Infants born to positive mothers: 0.5 mL IM at birth
- Household exposure: 0.5 mL plus Hepatitis B Vaccine
H-Big Side Effects
H-Big is associated with several side effects once the patient has been exposed to it. Therefore, this drug must be prescribed as per the instruction to reduce the chances of experiencing severe side effects. Usual or common side effects do not pose any threat to the patients but if they last for a long time, seek immediate medical attention. Below you will find a list of side effects associated with H-Big. Note that not all possible side effects are listed.
Common H-Big side effects:
- Stomach pain
- Mild itching or rash
Severe side effects:
- Slurred speech
- Poor vision
- Rapid weight gain
- Trouble breathing
- Sudden numbness
- Rapid heart rate
H-Big has been proven to interact with various drugs. It is therefore important to avoid taking this medication with other medication programs unless your doctor has confirmed that its safety. Drug interactions can be very dangerous to the patient's health and sometimes there can be very severe health complications. Tell your doctor about any medications you are taking, including over the counter drugs. Below you will find a list of drugs that may interact with H-Big. Note that not all possible interactions are listed.
- Biavax II