Brand Name(s): Sancuso
Drug Class: 5HT3 receptor antagonists
Treats: prevent nausea, vomiting
Granisetron HCL treats vomiting and nausea. Granisetron HCL is a 5-hydroxytryptamine receptor antagonists (5-HT3 RAs) and it has the ability to block serotonin. Granisetron HCL is effective prevention of chemotherapy-induced vomiting and nausea. Granisetron HCL function by blocking serotonin action on nerves that relays impulses to the brains from the intestines.
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Granisetron HCL Uses
Granisetron HCL function by blocking serotonin effects in the stomach and the brain. They relieve vomiting and nausea that occurs due to chemotherapy.
Before operation, patients take Granisetron HCL to curb cases of nausea and vomiting brought about by anesthesia. Granisetron HCL will reduce bumilia episodes in patients with bumilia Nervosa.
Radiotherapy and chemotherapy, destroy the cells that line the intestines, cells in turn discharge serotonin found in them. The released Granisetron HCL binds to nerves that relay impulses that induce vomiting from the gut to the vomit centre and later activate the vomiting reflex. Different conditions that Granisetron HCL treat include:
- Nausea/Vomiting that are Postoperative
- Nausea/Vomiting that are Radiation-Induced
- Obsessive Compulsive Disorder
- Postanesthetic Shivering
- Nausea/Vomiting that are Chemotherapy Induced
- Alcohol Dependence
Granisetron HCL Dosage
Below is the basic dosage that is used by most healthcare providers to give Granisetron HCL to their patients. However, depending on your condition and medical history, a physician might prescribe a different regimen. You should not change your dosage, stop, or start taking your medication without consulting your health provider.
Adult Dose for Nausea or Vomiting - Chemotherapy Induced
- IV: 10 mcg/kg over 5 minutes, it should begin 30 minutes before initiation of chemotherapy.
- When taking orally: 2 mg, given up to 1 hour before going for chemotherapy, or 1 mg twice a day. First dose to be taken up to 1 hour before chemotherapy, second dose to be taken 12 hours later.
Granisetron HCL Side Effects
Side effects of most drugs cannot be anticipated so if you notice any change in intensity or any developments while taking Granisetron HCL, it is recommended to see a doctor as soon as possible. Transmen and transwomen may also have side effects from Granisetron HCL. Pharmacists or Doctors are the only ones who can determine if it is safe to continue taking Granisetron HCL.
- Diarrhea or constipation.
- Muscle cramps
- Skin redness, rash, or blisters.
- Upset stomach
- Dry mouth and throat
- Dizziness and headache.
- Fatigue and sleepiness.
Rare side effect of Granisetron HCL include:
Granisetron HCL Interactions
There are various possible interactions with Granisetron HCL. That is drug, food, or lifestyle changes interactions. In the case of drug interactions, don't start or stop using the drug or even amend the prescribed dosage without consulting your doctor. A few of drugs that cause severe interactions with serotonin antagonists include:
- Tricyclic antidepressants, inhibit serotonin reuptake
- Selective serotonin reuptake inhibitors, inhibit serotonin reuptake
- L-Tryptophan, a serotonin precursor
- Anorectics and amphetamines, increase 5-HT release and reduce its reuptake
- Atypical antidepressants
- Buspirone, partial serotonin agonist
- Tramadol inhibits serotonin reuptake
- Monoamine oxide inhibitors, inhibit the metabolism of 5-HT
- Pethidine, a serotonin agonist
- LSD, partial serotonin agonist