Brand Name(s): Faslodex
Drug Class: Estrogen receptor antagonists
Treats: advanced breast cancer
Fulvestrant is an estrogen receptor antagonist that is used to treat advanced breast cancer in those who have already undergone menopause. The breast cancer is a hormone receptor positive meaning that it relies on hormones such as estrogen to develop. Therefore, Fulvestrant is used to treat individuals whose breast cancer has deteriorated after undergoing treatment using anti estrogen drugs such as tamoxifen (Nolvadex).
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As an estrogen receptor antagonist, Fulvestrant is used in the treatment of particular breast cancer that is hormone receptor positive in those who have undergone menopause. This type of breast cancerous cells require hormones such as estrogen to develop and multiply. Fulvestrant works by preventing estrogen from working on the particular cancerous cells, thus preventing the multiplication and development of the cancerous cells. As a result, Fulvestrant can slow down or discontinue the development of some breast growths that require estrogen to develop and multiply. Additionally, Fulvestrant can be used in individuals whose breast cancer has deteriorated after undertaking a treatment with other anti estrogen drugs such as tamoxifen (Nolvadex).
- Breast cancer
Dosage of Fulvestrant depends on the individual and the condition being treated. Fulvestrant should be used according to your doctor's recommendation. Therefore, you should strictly adhere to your doctor's reference and manufacturer's guidelines.
- The suggested administration of Fulvestrant is intramuscular, hence you should inject Fulvestrant slowly into the buttocks, at 1 to 2 minutes per injection in order to avoid injuring yourself in the process of administering the medication.
- Fulvestrant dosage is 500 mg that should be given as 2 x 250mg per 5ml injections.
- You should inject one 5ml of Fulvestrant on one side of the buttock and the other 5ml on the other side.
- Fulvestrant must be taken on days 1, 15, 29, thereafter administer Fulvestrant once monthly.
- Note that, in case you have a moderate hepatic impairment, you should take Fulvestrant as a dose of 250mg.
Fulvestrant Side Effects
Similar to any other medication, Fulvestrant has side effects that cannot be anticipated. Nevertheless, it is necessary that you notify your physician of any changes that occur in your body while undergoing treatment with Fulvestrant. Moreover, your doctor will determine whether the condition of any side effects will lead to the discontinuation of Fulvestrant. The list below comprises of the side effects that may occur while undergoing treatment with Fulvestrant though it is not exhaustive. Fulvestrant side effects include:
- Body pains or aches
- Loss of appetite
- Hot flashes
- Upset stomach
- Pain or swelling at the injected point
- Sleeping troubles
In most cases, various drugs should not be combined with Fulvestrant during treatment. Therefore, you should notify your physician of all the medicines, over the counter drugs, and herbal medication, before beginning treatment with Fulvestrant. Additionally, you should notify your doctor of your complete medical history and consult with your physician before taking any new medication. The reason is that interactions may cause an increase in the chance of getting adverse side effects when using Fulvestrant. Moreover, you should consult your doctor before starting, stopping, or changing the dosage of Fulvestrant.