Zoloft is a serotonin reuptake inhibitor that can be used for a variety of conditions, though its primary use is to treat depression. Though the causes of depression and how Zoloft works in the brain are not fully understood, it's thought that Zoloft increases the activity of serotonin in the brain, which relieves symptoms of depression. It does not affect dopamine or norepinephrine. Zoloft (Sertraline) is a special medication formulated to treat depression, social anxiety disorder, panic attacks, premenstrual dysphoric disorders and obsessive compulsive disorder. It is an antidepressant drug that works by affecting the chemical (serotonin) in the brain that might be imbalanced thus causing these conditions. Zoloft can also be used to improve mood, appetite and energy levels in the body. It may be used to decrease fear, unwanted thoughts such as suicidal thoughts and panic attacks. Zoloft should never be combined with pimozide and methylene blue injection. The drug is supplied in the form of tablets and should be administered through the mouth. Dosage should be determined by the age of the patients.