Sulfamylon is also known by its generic name, mafenide acetate solution. It is a type of sulfonamide medicine and belongs to a class of drugs referred to as sulfa antibiotics. Sulfamylon medicine is a topical cream and is applied directly to the skin. This drug works by killing the bacteria that would otherwise infect an open wound. By killing off the bacteria, Sulfamylon promotes healing of wounds and prevents the spread of the bacteria.