Prednisolone is a natural man-made substance produced by the adrenal gland. Prednisolone is used in the treatment of arthritis, immune system disorders and severe allergies. Prednisolone works by decreasing the response of the immune system in order to reduce symptoms such as swelling and pain. Prednisolone is a drug used in the treatment of a wide variety of inflammatory states. It can, for example, be used in the treatment of Crohn's disease, ulcerative colitis, psoriasis, lupus, and multiple sclerosis. The drug can also be used in the treatment of more serious conditions, such as temporal arteritis. Prednisolone belongs to the steroid class of drugs. It works by enhancing the effects of the glucocorticoid receptor, an enhancement that results in its anti-inflammatory and vasoconstrictive effects. As a steroid drug, prednisolone works in the nucleus of cells to exert its effects. Common side effects with prednisolone include nausea, hair thinning, skin thinning, bodily discomfort, and weight loss. Paradoxically, some patients experience weight gain with prednisolone.