IsonaRif is a combination medication that contains as rifamycin antibiotic, rifampin and an anti-infective, isoniazid. IsonaRif combination medication treats tuberculosis, TB. It applies alone or with other drugs for tuberculosis. IsonaRif is generically available as rifampin /isoniazid and includes in the drug category known as Antituberculosis combinations. IsonaRif has another brand name known as Rifamate.