Duloxetine is a drug used in the treatment of a wide variety of conditions - ranging from depression and generalised anxiety disorder (GAD) to diabetic neuropathy and fibromyalgia. It belongs to the SNRI class of drugs, which work by making serotonin and norepinephrine more available to neurons in the brain.Duloxetine HCl is a medication that is used to treat depression and anxiety. These are conditions that are believed to be as a result of chemical imbalances in the brain. This medication works by restoring the balance of the chemicals and other natural substances in the brain. Duloxetine HCl can also be used to treat peripheral neuropathy, a nerve pain condition mostly in people with diabetes. Duloxetine HCl can also be used in people suffering from ongoing pain due fibromyalgia, chronic back pain or arthritis. The drug will improve your mood, decrease nervousness, and improve your appetite. Duloxetine HCl should only treat depressive disorders in adults and children above the age of 7. It is available as tablets and capsules, and it is for oral administration only.