Desvenlafaxine is a drug used in the treatment of major depressive disorder. It works as an SNRI, which means that it prevents the reuptake of neurotransmitters such as norepinephrine and serotonin between nerves. This means that nerves are more exposed to the now increased levels of these neurotransmitters and, consequently, it alters the mood of those with depressive disorders. There are some clinically significant interactions with desvenlafaxine, not least its interaction with MAOIs. This latter class of drugs are also used in the treatment of mental disorders and, when combined, can potentially lead to coma and death.