Benefix is a coagulation factor IX, an artificially synthesized protein that is similar to the natural protein in the body, which helps in blood clotting. This man-made protein is produced using recombinant technology. It is a synthetic protein that takes the form of factor IX in body. Benefix helps in controlling, treating, or preventing the bleeding that is associated with hemophilia B. This medication may be used to control bleeding among patients with hemophilia B who are undergoing surgery.