Androgel is a medical gel used for hormone replacement in men who are unable to produce testosterone naturally. A lack of the testosterone hormone can cause decreased libido, brittle bones and depression in men. Androgel is a gel that is absorbed through the skin. Androgel works by entering one's bloodstream to create a normal testosterone level. Androgel is a medicated gel that contains testosterone. Androgel is used for hormone replacement in adult males whose bodies are not able to generate enough testosterone. Androgel is absorbed through the skin. Once in the bloodstream, Androgel helps the body achieve normal testosterone levels. Testosterone is a hormone that helps the body develop and maintain masculinity (male sexual characteristics) such as body hair and deep voice. Testosterone also helps maintain and reduce bone loss. It is also required for natural sexual ability and desire. Women should not use Androgel. Androgel is applied directly on the skin. Be sure to clean the skin and pat it dry before applying.