Adapalene is a drug used in the treatment of mild to moderate acne. The drug may also be used off-label in the treatment of keratosis pilaris. As a form of vitamin A, adapalene works by inhibiting keratinocyte differentiation, resulting in a marked anti-inflammatory and exfoliating effect. Common side-effects include burning, stinging and itching at the site of application.
Adapalene is found in gel or topical cream form used to treat mild acne to relieve acne, as well as keratosis pilaris and blackheads and white heads. It comes under the trade names Differin, Teva, Pimple, Gallet, Adeline, and Adaferin. It is a prescription drug that reduces inflammation, exfoliates and drastically reduces the number of open and closed comedo (black heads and white heads). Adapalene also treats pustular acne.Adapalene must be stored at room temperature so that the active ingredients of sodium hydroxide, propylene glycol, and methylparaben poloxamer 124 do not react with intense heat. These ingredients reduce the swelling caused by the comedo.