Generic Name(s): Alemtuzumab
Drug Class: Monoclonal antibodies
Treats: Multiple sclerosis, organ transplant rejection,
Campath is a colorless, sterile, isotonic and clear solution for injection, with no added preservatives. It is a treatment for a certain leukemia type that stops the growth of cancer cells. Monoclonal antibody Campath can only be prescribed via the program of Lemtrada Risk Evaluation and Mitigation Strategies. Taking Campath may increase risk of cancer in the thyroid, lymphoma, and skin. The medication may even result in fatal issues in the autoimmune system.
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Campath uses are for addressing multiple sclerosis, or B-CLL, the B-cell chronic lymphocytic leukemia, as well as other conditions determined by the doctor. It is not known how it exactly deals with MS. The drug is not a treatment of MS but helps prevent the cells of the immune system from attacking the nerves in the spinal cord and in the brain, thereby, decreasing the frequency of worse episodes and delaying disability. Using Campath exposes the patient to certain side effects, such as problems in the blood. These serious problems may come while taking Campath or even years after treatment. Patients should have their urine and blood checked while taking the medicine, and even after the treatment. They should also talk to their doctor regularly.
- Multiple Sclerosis
- B-Cell Chronic Lymphocytic Leukemia
As a drug that is usually administered by a medical professional, Campath dosage should not be administered as an intravenous push or bolus. Recommended Campath dosage is seen below. Note the dosage is an average dose and individuals should follow their medical professionals dosing information.
- Campath is administered every 2 hours.
- Gradual increase to the maximum single Campath dosage of 30 mg
- Dosing escalation is needed at dosing initiation, or if treatment is held for more than 7 days
- Increase of dosing to 30 mg is normally accomplished in 3 to 7 days
- Campath dosage strategy follows: Administration of 3 mg per day until it reaches a certain infusion reaction phase 3. 0 mg daily 3 times a week on alternate days. The total therapy duration is 12 weeks. Single Campath doses more than 30 mg or more than 90 mg weekly may increase pancytopenia incidence
Campath Side Effects
There can be Campath side effects which can, at times, lead to serious and fatal reactions to infusion. The health professional will monitor the patient closely during the infusion and 2 hours thereafter. Serious reactions can even happen up to 24 hours after receiving Campath. The patient should be alert to inform the doctor if he or she feels any of the side effects below. The below list of Campath side effects is not complete. Patients should report them to their doctor immediately whatever signs of change in health conditions they experience.
- Chest pain or tightness
- Severe dizziness or headache
- Stomach upset
- Irregular, slow or fast heartbeat
- Hives, rash and itching
- Shortness of breath
- Wheezing and unusual hoarseness
- Swelling of the lips, face and other areas
- Flushing, sleeping difficulty and weakness
When taken with other medications, the patient may possibly suffer dangerous drug interactions. Campath interactions can be serious side effects. Some of the products that may result in Campath interactions are listed below. Note, this list does not include all possible interactions.
- Smallpox vaccine
- Dryvax Leflunomide
- Arava Measles virus vaccine
- Aubagio Mumps or rubella virus vaccine
- Biavax II
- Meruvax Clozapine
- influenza virus vaccine
- measles virus vaccine
- rotavirus vaccine
- varicella virus vaccine
- yellow fever vaccine
- Vax Zoster vaccine live