Angiotensin receptor blockers (ARB) plus calcium channel blocker combination (CCB) are used mainly to prevent cardiovascular events in chronic kidney disease better than a dose of ARB alone. However, it is not yet established which ARB based combination therapy is effective and safe. It is now recommended that when taking combination treatment for hypertension the patient needs to always include a diuretic as one of the agents and adding calcium channel blocker will invariably be a part of that.
Calcium Channel Blocker + ARB Combinations Drugs
Combination drugs that are considered Calcium channel blockers and ARB inhibitors include:
Calcium Channel Blocker + ARB Combinations Uses
The combination of ARB and CCB is used in treating hypertension. This combination treatment has increased a proportion of patients to achieve blood pressure control, but there is a significant number of patients have their blood pressure rise above the recommended values. This combination is a rational approach in such antihypertensive measures by lowering incidences of adverse events. ARBs protect against stroke, renal protection and tolerability without any dose-related metabolic and symptomatic adverse reactions. CCBs are beneficial in treating cardiac ischemia and reducing stroke.
To patients who suffer from hypertension, the calcium channel blocker/renin-angiotensin system blocker combination reduces the risk of calcium channel blocker associated peripheral edema when compared with calcium channel blocker immunotherapy. ACE inhibitor seems to be more efficacious than ARB in reducing calcium channel blocker-associated peripheral edema, but a lot of studies are needed to be conducted to prove this.
Calcium Channel Blocker + ARB Combinations Side Effects
The side effects of this combination vary with the specific agent used.
- Overgrowth of the gum tissue
- Swelling of the extremities
- Muscle cramps
- Abdominal pain
- Heart rhythm problems
Calcium Channel Blocker + ARB Combinations Interactions
When taking this medication you should at all time avoid grapefruit and grapefruit juice this can affect actions of CCBs, before taking the drug ask your pharmacist first if your CCB is affected by grapefruit juice.
Do not consume alcohol since it interferes with the effects of the drug and may result in an increase in side effects.
Discuss with your doctor or medical professional the best way to take this medication if you are taking other drugs. This is because other blood pressure medications in combination with CCBs can cause a drastic sudden drop in blood pressure.