Brand Name(s): Targretin Topical
Drug Class: Retinoids
Treats: Skin lesions caused by cutaneous T-cell lymphoma (CTCL)
Bexarotene (Targretin) is a prescription medicine that is used to treat cutaneous T-cell lymphoma (CTCL). Bexarotene (topical) inhibits the growth of the malignant cells in the body and harms cancer cells causing their death. Bexarotene (topical) is given only when other cancer medications fail to treat the disease. Bexarotene (topical) comes in the form of a gel that is applied to the affected area as prescribed by the doctor.
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Bexarotene (topical) Uses
Bexarotene (Targretin) belongs to a member of a subclass of retinoid that selectively activate retinoid X receptors. Bexarotene works by selectively binding to the retinoid X receptors and activates them. Once these receptors are activated, they function as transcription factors responsible for regulating the expression of genes that control cellular differentiation and proliferation, thus inducing tumor regression. It is important to note that Bexarotene (topical) is not for people who are allergic to this medicine. Pregnant individuals should not be given this medication.
Below you will find the different types of cancers that can be treated by using Bexarotene:
- Cutaneous T-cell Lymphoma
Bexarotene (topical) Dosage
Bexarotene dosage will depend on the person who takes it. The gel is applied on the affected area only once a day for the first week. After that the frequency of application needs to be increased at weekly intervals. For instance, once a day, then twice a day, then three times a day and finally, four times a day as per the tolerance limit of an individual. If any toxicity is seen at the application site, application frequency can be reduced or discontinued temporarily. It is also advised to consult a doctor if any you experience any kind of irritation or side-effects. Below you will find a typical dosage of Bexarotene topical.
- Apply the gel to affected area once daily
- Increase dosage as instructed by your doctor
Bexarotene (topical) Side Effects
Bexarotene (topical), like any other drug, comes with its collection of side effects that vary with each who uses it. If you experience any severe side effects, consult your doctor or medical professional immediately. Bexarotene is for external use only. Do not apply the gel on body parts such as eyes, mouth, nostrils, vagina, the tip of the penis and rectum. Below you will find a list of side effects associated with Bexarotene topical. Note that not all possible side effects are listed.
- Bloating or swelling of face, hands, lower legs
- Loss of strength
- Thickened scaly skin
- Skin rash, blisters, redness, or irritation
- Sore throat
- Unusual tiredness or weakness
- Abnormal or excessive sweating
- Painful or difficult urination
Bexarotene (topical) Interactions
Do not use Bexarotene (topical) without the recommendation of a doctor, as some drugs may interact with others and increase your risk of serious side effects or may cause medications not to work efficiently. Besides, you must tell your doctor about any other medications that you are using for the treatment of other health conditions. Below you'll find a list of Bexarotene (topical) drug interactions.
Drugs that interact with Bexarotene (topical):
- Aminolevulinic acid topical
- Methyl aminolevulinate topical
- Levulan Kerastick (aminolevulinic acid topical)
- Metvixia (methyl aminolevulinate topical)
Do not stop or change the drug dose without informing your doctor. Only a certified health care professional can alter or change the dose of Bexarotene.