Brand Name(s): Inlyta
Drug Class: Kinase inhibitor
Treats: advanced kidney cancer
Axitinib is a small molecule tyrosine kinase inhibitor medicine. This drug interferes with the growth and multiplication of cancer cells. Axitinib is a generic drug and the brand version of this medicine in Inlyta. This medicine is often used after other drugs have been tried without success. Axitinib is classified as a Kinase inhibitor.
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Axitinib use is indicated for the treatment of advanced renal cell cancer after unsuccessful treatment using other systemic therapy. Doctors prescribe Axitinib use to treat advanced kidney cancer after all other medicines have been unsuccessfully used to treat the cancer. Axitinib clinical trials have shown it significantly inhibits growth of breast cancer in animals and other types of tumors in humans. However, reports indicate the possibility of fatal adverse effects. The US FDA approved this medicine which was developed by Pfizer after exhibiting a modest increase in progressionfree survival.
- Advanced Renal Cell Cancer
- Advanced Kidney Cancer
Axitinib dosage is recommended by the doctor after a careful examination of the patient. Dosage depends on the condition being treated, patient’s weight, age and other factors.
- The recommended starting dose for Axitinib is 5 mg administered 2 times per day. Axitinib is an oral medicine and should be taken by mouth.
- Each dose should be taken with or without food about 12 hours apart. It is important to take this medicine at approximately the same time every day.
- A missed or vomited dose should not be taken but patient to continue with the next dose. Axitinib dose modification can be recommended based on tolerance and individual safety.
Axinitib Side Effects
Axitinib can be very toxic, and patients are likely to suffer from its side effects. Some of the most common Axitinib side effects are said to occur in at least 20 percent of patients. Not all side effects may be reported, and others may occur. These and any serious side effects or allergic reactions should be reported to the doctor for immediate medical attention. The following is a list of common Axitinib side effects:
- Problems with blood clots in blood vessels
- High blood pressure
- Thyroid gland problems
- Perforations in stomach or intestinal walls
- Heart failure
- Higher protein levels in urine
- Diarrhea, nausea
- Vomiting, constipation
- Reduced appetite
- Feeling tired, weak
- Constipation, diarrhea
This is not a complete list of side effects and others too, may occur. These can be reported to the doctor for further attention.
Drug interactions can affect the way the drug works. Axitinib interactions with other drugs or products may render it ineffective or result in adverse effects or allergic reactions. Writing down a list of all products and drugs a patient may be using is important so as to allow doctors to check for possible drug interactions. The following medicines and products are usually checked for possible Axitinib interactions: