Drug Class: non-depolarizing neuromuscular-blocking drug
Treats: endotrecheal intubation, relaxation of skeletal muscles, facilitate mechanical ventilation
Atracurium Besylate is an intermediate duration nondepolarizing, nueromuscular blocking drug which is administered intravenously. Also called skeletal muscle relaxant, the drug is used with anaesthesia during surgery to provide relaxation of the muscles. The administration of the drug is to be performed by trained doctors only. Atracurium Besylate also helps in mechanical respiration of patients in ICU.
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Atracurium Besylate Uses
Atracurium Besylate belongs to the drug class of nondepolarizing skeletal muscle relaxants or neuromuscular blocking drugs. Neuromuscular blocking drugs work by paralysing the vocal chords and relaxation of skeletal muscles. The uses of Atracurium Besylate are as follows:
- To relax skeletal muscles during surgery (used along with anaesthesia)
- To relax the vocal chords for endotrechael intubation and mechanical ventilation
- To help the mechanical ventilation of patients in ICU.
The administration of the medicine is done during surgery, after the patient is made unconscious. Since, it is important to stabilize the breathing of the patient, a mechanical ventilator is often used.
Atracurium Besylate Dosage
Atracurium Besylate is administered as intravenously and not intramuscularly since it can cause tissue irritation. Also, to avoid inconvenience to the patient, the drug must be administered only when a state of unconsciousness has been induced.
Also, alkaline solutions must not be used in the same syringe as used for Atracurium Besylate. As with every neuromuscular, it is important to monitor the dose for individual patients. The recommended dosage of Atracurium Besylate is as follows:
- Initial Dosage: 0.3 to 0.6 mg/kg given as an intravenous injection. It takes around 90 to 120 seconds for the accomplishment of Endotracheal intubation.
- Maintenance Dosage: Maintenance dosage of Endotracheal intubation is used in prolonged surgical process. The average maintenance dose is 0.1 to 0.2 mg/kg.
Atracurium Besylate Side Effects
As with other drugs, Atracurium Besylate is also accompanied by a few side effects. Although, these adverse reactions are not very common, it is always advisable to consult your doctor if you experience any abnormality. Many side effects of Atracurium Besylate occur due to histamine release. These side effects are usually dermatoligical in nature. Here is a list of side effects of Atracurium Besylate:
- Rash in the area of drug administration
- Changes in blood pressure
- Prolonged block of the skeletal muscles
- Inadiquate block of the skeletal muscles
The list does not contain all the side effects of Atracurium Besylate. Therefore, consultation with the doctor is a must in case of any abnormality.
Atracurium Besylate Interactions
The duration as well as effect of non depolarizing neuromuscular blockers like Atracurium Besylate can be aggravated when interacted with other drugs. As with any medication, it is important to inform your doctor about all the medicines you are taking. Take a list of prescription, non prescription as well as herbal medicines and supplements while discussing your treatment. This will be important to avoid any kind of distress in the future.
Here is a list of some common drug interactions with Atracurium Besylate:
- Beta Blockers
- Antirheumatic drugs
- Lithium and magnesium salts
- Calcium channel blockers