Generic Name(s): Antithrombin III
Drug Class: Parenteral anticoagulant
Treats: Deficiency of anticlotting agents, Venous thromboembolism
Atnativ is a trade name for Antithrombin III Intravenous, a recombinant made inhibitor used for treatment of deficiency of anticlotting agents through inhibition of several clotting factors, including thrombin. Upon administration of Atnativ, it acts by binding to thrombin and then forms the thrombin-antithrombin complex which is activated by presence of heparin.
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Atnativ is primarily injected to patients with deficient antithrombin III concentrate and especially for patient with recurrent thromboembolism and pulmonary embolism. Atnativ inhibits several activated coagulation factors of the intrinsic and common pathways including thrombin, Xa and IXa. The action of antithrombin III is activated by heparin, a compound released by basophils and mast cells.
Heparin increases the rate of the thrombin-antithrombin reaction at least 1000-fold by serving as a catalytic template to which both the inhibitor and the protease bind thus preventing the conversion of fibrinogen into fibrin. Antithrombin III deficiency is a rare hereditary disorder common in patients who suffers recurrent venous thrombosis and pulmonary embolism. Therefore, Atnativ is used by patients with conditions such as;
- Venous thromboembolism
- Pulmonary embolism
Your doctor will determine the Atnativ dosage depending on a number of factors such as weight, medical history, other medical conditions or other medications that you may be using. Stick to the Atnativ dose as directed by the doctor and never alter the dosage plan unless authorized by the doctor.
Atnativ is a recombinant derived concentrate indicated for prevention of perioperative and peripartum thromboembolic events in patient with hereditary antithrombin III deficiency. It is usually available as a lyophilized powder which is reconstituted for IV infusion.
Dosage for prophylaxis and treatment of thromboembolism ;
- Initial dose is individualized to quantity required to increase antithrombin III activity to 120% of normal activity as determined 30 minutes after administration. Usual infusion rate is 50 -100 IU/minute I.V.
Dosage to be administered is calculated using this formula:
Units required (IU) = [desired-baseline Atnativ level] x Weight (kg)/ 1.4
Treatment usually takes 2- 8 days.
Normally administered as a continuous parenteral infusion.Increase, reduction or cessation of Atnativ dose should always be determined by your doctor.
Atnativ Side Effects
Using Atnativ may have side effects that may differ from one person to the other. The acuteness of the side effects may be different from one patient to the other depending on the patient’s body ability to handle the effects of the drug. Stop using Atnativ and report severe side effects to your doctor immediately. Seek medical attention if any of the following symptoms become severe or bothersome:
- Difficult breathing
- Pruritus at site of injection
Call your doctor immediately if the following serious side effects manifest:
- Chest pain
- Hepatic enzyme changes
- Hypersensitivity reactions
- Wound secretion
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Before taking Atnativ with other drugs, inform your doctor about any medical conditions or allergies that you may have. This is because using Atnativ with other drugs may affect how the drug works and delay the expected results. Below is a list of possible drug interactions with Atnativ that should be checked or avoided altogether:
- Lepirudin, Bivalirudin, Argatroban, Danaparoid.
- Azithromycin, Clarithromycin
- Cephalosporin antibiotics
- Oral contraceptives
This is not an all-inclusive list of possible drug interactions. You should keep a list of all products you may be using (including prescription/OTC drugs and herbal products) and share it with your doctor and pharmacist. Do not starts, stop, or alter the dosage of any medicines without approval from your doctor.