Generic Name(s): Metrizamide
Drug Class: nonionic radiopaque contrast agent
Amipaque is a nonionic radiopaque contrast agent and is indicated in pediatric and adults patients for cervical, lumbar, thoracic and total columnar myelography to get to know if there is the presence of abnormalities in the spinal canal, spinal column, and the central nervous system.
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Amipaque is used in pediatric patients for cisternography by direct injection using the standard procedures to visualize the basal cistern of the brain. Amipaque is also indicated in:
- pediatric patients for ventriculography by direct injection using normal procedures to visualize the cerebral ventricles.
- Amipaque can also be used in adult peripheral arteriography to visualize specific region of the blood flow and vascular system in such areas to assist in evaluating and diagnosing of neoplasms or vascular diseases that may bring changes in normal physiology or vascular anatomy.
- Amipaque is indicated in pediatric angiocardiography to visualize malformations or lesions of the heart and blockages or anomalies of the major thoracic vessels.
Below is the basic dosage that is used by most healthcare providers to give Amipaque to their patients. However, depending on your condition and medical history, a physician might prescribe a different regimen. You should not change your dosage, stop, or start taking your medication without consulting your health provider.
Adult and adolescent dose (Intrathecal)
- Lumbar myelography by lumbar injection— use 10 to 15 mL of a solution containing the corresponding of 170 to 190 mg of iodine per mL.
- Thoracic myelography by lumbar injection— use 12 mL of a solution containing the equivalent of 220 mg of iodine per mL.
- Cervical myelography by lumbar injection— use 10 mL of a solution containing the equivalent of 250 to 300 mg of iodine per mL.
Amipaque Side Effects
Amipaque, just like any other medication, may have its unwanted effects. Side effects vary depending on technique and amount used, concentration of the contrast agent, and the underlying pathology. In the unlikely situation that you experience any side effects with Amipaque, tell your doctor immediately.
Less frequent or rare effects of Amipaque include:
- Severe weakness or tiredness
- skin rash or hives
- stuffy nose
- swelling of face or skin
- swelling of the tongue
- tightness in chest
- troubled breathing
rare side effects of Amipaque include:
- paralysis of one pf legs and arms or body
- severe vomiting and nausea
- focal, seizures, or generalized grand mal
There are possible drug interactions with Amipaque and you should not start, stop, or change the dosage prescribed by your doctor without consulting them. Some of the medications that can cause severe interactions with Amipaque include:
- Antidepressants, tricyclic or CNS stimulation
- Monoamine oxidase (MAO) inhibitors, including procarbazine, furazolidone, and selegiline
- Beta-adrenergic blocking agents
- Cholecystographic agents, oral
- Glucocorticoids, intrathecal
- Hypotension-producing medications
- Nephrotoxic medications