Generic Name(s): Tetrabenazine
Drug Class: VMAT inhibitors
Treats: Huntington's disease
Xenazine is a drug that belongs to the central nervous system agents. Xenazine has an active ingredient called tetrabenazine. Xenazine ideally is used to treat the symptoms of Huntington's disease. These symptoms include the uncontrollable movements associated with Huntington's, also known as chorea. This will help the patients that are suffering from Huntington's diseases to carry on with their daily routines. Xenazine treats these symptoms by reducing the availability of certain chemicals in the brain like dopamine that causes excitation of the neurones.
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Apart from chorea (uncontrollable movement), Xenazine can also be used to treat other symptoms of hyperkinetic movement disorder. The active component known as tetrabenazine acts on some chemicals on the brain that are responsible for exciting the neurons and cause uncontrollable movement. Xenazine works by reversibly depleting certain monoamines like histamine, dopamine, norepinephrine and serotonin from the nerve terminals. Xenazine is able to inhibit the uptake of monoamines into the synaptic, which will lead to the depletion of monoamine stores after it inhibits the type 2 monoamine transporter. The following are the various hyperkinetic disorders for which Xenazine can be used as treatment and not a cure.
- Tourette syndrome
- Tardive dyskinesia
- Huntington's disease
Xenazine is a prescribed substance and this means that if you are to reap maximum results from the treatment plan you should stick to it and the formulated dosage. You should only alter your dose if asked to do so by your doctor or prescribing pharmacist, doing so without their consent could jeopardise your response to the treatment while putting you at at serious risk of side effects. Your dosage of Xenazine will be structured based on the following factors
- Your medical condition
- Your response to the treatment
- Your body's ability to handle the drug
Below you will find a typical dosage of Xenazine.
- The initial dose is set at 12.5 mg of Xenazine administered orally once daily before or after meals.
- The maintenance dose is increased up to 25 mg daily and is split into equal doses of 12.5 mg administered twice a day.
- The maximum daily dose is set at 25 mg.
Xenazine Side Effects
The use of most prescription drugs may be accompanied by the occurrence of some side effects. This is also the case with Xenazine, its use may be accompanied by the occurrence of some undesired symptoms. These side effects may vary from one individual to another and in some rare cases may even fail to be experienced by some individuals. Side effects can, however, be dealt with and should therefore not stop you from finishing your set dose and treatment regimen. You can consult your doctor on how to deal with the anticipated symptoms. Some of the common side effects that may occur include the following. Note that not all possible Xenazine side effects are listed.
- Dizzy spells
These side effects may fade away gradually without medical attention, however, if these symptoms persist or if you experience the below symptoms alert your doctor promptly:
- Mental changes like depression
- Suicidal tendencies
- Muscle rigidity
- Poor coordination
- Decreased libido
- Breast enlargement
- Allergy symptoms
- Severe dizzy spells
- Difficulties breathing
- Irregular cardiac rhythms
Like any drug, Xenazine may interact with other drugs and substances. Drug interactions need to be closely monitored because they tend to influence the performance of the drug and its ability to deliver the desired effects during a treatment regimen, not only this, interactions also put you at a serious risk of experiencing adverse side effects. You should diligently inform your doctor or prescribing pharmacist about all the substances you might be taking prior to your first administration of Xenazine.These substances may be either prescribed or over the counter substances, vitamins and supplements. Below you will find a list of drugs that may interact with Xenazine. Note that not all possible interactions are listed.