TNF Inhibitors Drug Class

TNF Inhibitor, Tumor-Necrosis-Factor Alpha Blockers are biological medications that block the action of tumor necrosis factor, TNF. Tumor necrosis factor is a chemical in the body that triggers inflammation and result in immune system diseases like ulcerative colitis, Crohn’s disease, rheumatoid arthritis and psoriatic arthritis. Other disorders like ankylosing spondylitis and plaque psoriasis also result. TNF inhibitors restrain the immune system by disrupting the TNF activities. Some of the medication in this class are; Enbrel (etanercept), Humira (adalimumab), Remicade (infliximab), Simponi (golimumab) and Cimzia (certolizumab pegol). In excessive concentrations, TNF inhibitors destroy the inflammatory activities that result, for example, bone RA and articular cartilage.

TNF Inhibitors Drugs

Below is the list of the common serotonin antagonists’ drugs.

TNF Inhibitors Uses

TNF inhibitors, the biological drugs mediate inflammation when in excess concentration. These medications block the activities of the TNF factors that bring about inflammation and other disorders and on the course weaken the immune system. There are several conditions that TNF inhibitors treat. They include:

  • Pulmonary Fibrosis, Ankylosing Spondylitis
  • Behcet’s Disease Bullous Pemphigoid, Pemphigus
  • Celiac Disease, Crohn’s Disease, Plaque Psoriasis
  • Wegener’s Granulomatosis Crohn’s Disease, Uveitis
  • Giant Cell Arteritis, Pemphigoid, Still’s Disease
  • Sjogren’s Syndrome, Histiocytosis, Sarcoidosis,
  • Inflammatory Bowel Disease, Alzheimer’s Disease
  • Juvenile Idiopathic Arthritis Kawasaki Disease
  • Macrophage Activation Syndrome, Ulcerative Colitis,
  • Rheumatoid Arthritis Neurosarcoidosis,
  • Polychondritis Psoriasis, Psoriatic Arthritis,
  • Pyoderma Gangrenosum, Crohn’s Disease,
  • Acute Reiter’s Syndrome, , SAPHO Syndrome,
  • Juvenile Rheumatoid Arthritis Spondyloarthritis,
  • Subcorneal Pustular Dermatosis Toxic Epidermal Necrolysis,
  • Cogan’s Syndrome

TNF Inhibitors Side Effects

There are various side effects brought about by drugs in class TNF inhibitors. Any unlikely situation you might experience, immediately seek medical attention. More common

  • Body aches or pain
  • Cough or hoarseness
  • Ear congestion
  • Lightheadedness
  • Loss of voice
  • Lower back or side pain
  • Muscle aches and pains
  • Nasal congestion
  • shivering
  • sunken eyes
  • thirst
  • trouble sleeping
  • warmth on the skin
  • wrinkled skin

Less common

  • Hair Loss
  • Hallucinations
  • Headache
  • Increased Thirst
  • Inverted Nipple
  • Irregular Breathing
  • Irregular Pulse
  • Irritability
  • Itching Or Rash
  • Light Colored Stools
  • Loss Of Appetite

Rare but severe

  • tuberculosis
  • Septicaemia

TNF Inhibitors Interactions

There are various possible interactions with TNF blockers. In the case of drug interactions, don’t start or stop using the drug or even amend the prescribed dosage without consulting your doctor. A few of drugs that cause severe interactions with TNF inhibitors include: