Serotonin Antagonists Drug Class

Serotonin Antagonists are a category of medication that treats vomiting and nausea. 5-hydroxytryptamine receptor antagonists (5-HT3 RAs) got their name due to their ability in blocking serotonin, also known as 5-hydroxytryptamine, from charging the nerves result in vomiting reflex. Serotonin antagonists are the latest selection of anti-vomiting medicines on the market. There are various serotonin blockers drugs that are currently in the market for effective prevention of chemotherapy-induced vomiting and nausea. They include ondansentron, dolasentron, tropisetron, granisetron and palonosetron. They function by blocking serotonin action on nerves that relays impulses to the brains from the intestines.

Serotonin Antagonists Drugs

Below is the list of the common serotonin antagonists’ drugs.

Serotonin Antagonists Uses

Serotonin antagonists function by blocking serotonin effects in the stomach and the brain. They relieve vomiting and nausea that occurs due to chemotherapy. Before operation, patients take serotonin antagonists to curb cases of nausea and vomiting brought about by anesthesia. They reduce bulimic episodes in patients with bulimia Nervosa. Radiotherapy and chemotherapy, destroy the cells that line the intestines, cells in turn discharge serotonin found in them. The released serotonin binds to nerves that relay impulses that induce vomiting from the gut to the vomit centre and later activate the vomiting reflex. Different conditions that serotonin antagonists treat include:

  • Alcohol Dependence
  • Gastroenteritis
  • Nausea/Vomiting
  • Nausea/Vomiting that are Chemotherapy Induced
  • Nausea/Vomiting that are Postoperative
  • Nausea/Vomiting that are Radiation-Induced
  • Obsessive Compulsive Disorder
  • Postanesthetic Shivering
  • Pruritus

Serotonin Antagonists Side Effects

Serotonin antagonists, just like other medications, may have their unwanted effects. Any unlikely situation you might experience, immediately seek medical attention. Serotonin antagonists cause fewer side effects as compared to antinausea drugs. The side effects include:

  • Diarrhea or constipation
  • Dizziness and headache
  • Fatigue and sleepiness.
  • Muscle cramps
  • Upset stomach
  • headache
  • Confusion
  • Fatigue
  • sleepiness
  • Nervousness.
  • Skin redness, rash, or blisters
  • Dry mouth and throat

Rare side effect

  • Priapism

Serotonin Antagonists Interactions

There are various possible interactions with serotonin antagonists. That is drug, food, or lifestyle changes interactions. Severe serotonin syndrome is one of the conditions that develop as a result of drug interaction with serotonin antagonists such as cyproheptadine interacting with serotonergic medications. In the case of drug interactions, don’t start or stop using the drug or even amend the prescribed dosage without consulting your doctor. A few of drugs that cause severe interactions with serotonin antagonists include:

  • L-Tryptophan, a serotonin precursor
  • Tricyclic antidepressants, inhibit serotonin reuptake
  • Selective serotonin reuptake inhibitors, inhibit serotonin reuptake
  • Monoamine oxide inhibitors, inhibit the metabolism of 5-HT
  • Pethidine, a serotonin agonist
  • Buspirone, partial serotonin agonist
  • Tramadol inhibits serotonin reuptake
  • LSD, partial serotonin agonist
  • Anorectics and amphetamines, increase 5-HT release and reduce its reuptake
  • Atypical antidepressants
  • lithium