HIV NRTI + Integrase Strand Transfer Inhibitor Com Drug Class Overview, Drugs, Uses, Side Effects, and Interactions

Combinations of Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs) and Integrase Strand Transfer Inhibitors (ISTIs) are often prescribed to treat human immunodeficiency virus (HIV). Using multiple drugs as a combination to target different parts of the virus is referred to as highly active antiretroviral therapy (HAART). They work together by targeting different areas affected by the virus. NRTIs work against a substance called reverse transcriptase, which HIV uses to infect immune system cells. ISTIs target the actions of integrase, which helps integrate viral DNA into the host chromosome. Using drugs singularly or improperly to treat HIV can result in drug-resistant strains of the virus, which is why physicians usually prescribe medications in tandem. Combination therapies defend against resistance by further repressing replication.

HIV NRTI + Integrase Strand Transfer Inhibitor Com Drugs

There are several different types of both of these classes of drugs that can be used together in a variety of combinations. All of the drugs on these lists have been approved for use by the U.S. Food and Drug Administration.

ISTIs:

NRTIs:

HIV NRTI + Integrase Strand Transfer Inhibitor Com Uses

These two drugs are only ever used in the treatment of human immunodeficiency virus. Because of scientific advances such as these medications, HIV has been transformed from a death sentence to a moderate chronic illness. These two drugs are almost always combined using two NRTIs and one ISTI. NRTIs, however, are also often used in conjunction with other drugs. ISTIs are approved for use both in patients new to HIV treatment and patients who have been undergoing treatment for some time, but are most commonly prescribed to those who have already been receiving treatment. Since the two drugs are prescribed together, they are sometimes available in a single medication. Those medications are referred to as fixed-dose combinations.

HIV NRTI + Integrase Strand Transfer Inhibitor Com Side Effects

The side effects of this combination are smaller than most combination therapies for HIV. ISTIs are especially well-tolerated, although due to limited testing not much information is available on long-term consequences of their use. There aren’t particular side effects of the combination, but NRTIs can lead to the following conditions:

  • Lipoatrophy
  • Peripheral neuropathy
  • Myopathy
  • Liver steatosis
  • High levels of lactate

HIV NRTI + Integrase Strand Transfer Inhibitor Com Interactions

These drugs interact very well with each other. While limited information is available on how the combination interacts with other things, each drug comes with a lengthy list of things to avoid. Before beginning this combination, speak with your doctor about possible negative interactions.