GLP-1 Agonists _ or glucagon-like peptide (GLP)-1 receptor agonists are an injected class of drugs and an important therapeutic approach for treating type 2 diabetes. According to clinical data, GLP-1 Agonists improve glycemic control while simultaneously lowering both systolic blood pressure (SBP) and overall body weight in patients with type 2 diabetes. Additionally, hypoglycemia is very rarely reported with the use of this medication in these patients. GLP-1 Agonists achieve these results by mimicking the action of GLP-1 in order to increase the incretin effect in patients with type 2 diabetes, thus stimulated the release of insulin. They also aid with the secondary results of weight loss and lowered SBP by reducing glucagon, slowing gastric emptying and inducing satiety.
GLP-1 Agonists Drugs
The fowling drugs fall under the class of GLP-1 Agonists:
GLP-1 Agonists Uses
As with any other diabetes medication, a GLP-1 Agonist works best when the patient follows a full treatment plan in conjunction with the use of these drugs. For instance, it is important to continue to check blood glucose regularly, follow a healthy diet and meal plan and exercise on a daily basis.
That being said a GLP-1 Agonist works with other diabetes medications, usually pills and not insulin, to help control your blood glucose. GLP-1 Agonists are taken by injection, with most brands available as a pre filled dosing pen. They then work with the body to control blood glucose by slowing the emptying of the stomach after a meal, inhibiting the release of glucose from the liver and helping the patient eat less by helping them feel more full after meals and/or lowering the appetite in order to prevent overeating in the first place.
It should be noted that GLP-1 Agonist medications are not a cure for diabetes but rather a treatment that help control blood glucose. As such, they lower the chance that your diabetes will cause serious problems, particularly if usage begins as soon as possible after diagnosis. The drugs work this way by preventing high blood glucose _ an issue that can damage your blood vessels and nerves. Therefore, they help to prevent a heart attack, stroke, kidney disease and many health issues caused by that damage.
GLP-1 Agonists Side Effects
Common side effects of using GLP-1 Agonists, which you should call your doctor if you experience severely, include:
- Upset Stomach
- An overall jittery feeling
Call your doctor, healthcare provider, or 911 if you have any of these potentially serious symptoms:
- Hives, rash, or itching
- Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower legs
- Ongoing pain that begins in the upper left or middle of the stomach but may spread to the back, or any ongoing pain or ache in the mid or lower back
- Difficulty breathing or swallowing
- Lump or swelling in the neck
- Changes in the color or amount of urine
GLP-1 Agonists Interactions
Common drug interactions with GLP-1 Agonists include:
Food interactions with GLP-1 Agonists include:
- Alcohol _ may affect blood glucose levels in patients with diabetes. Both hypoglycemia and hyperglycemia may occur.
- Food _ these medications should be taken with the 60 minutes before meals, and at least six hours apart. It is possible to experience decreased absorption in the presence of food or other medications.