EGFR Inhibitors Drug Class

EGFR inhibitors prevent the progression of various cancers. These drugs are categorized according to their mode of treating a given disease state or through their active ingredients. EGFR inhibitors act on the epidermal growth factor receptor (EGFR) hence initiating a cascade of events that culminates in the inhibition of production of certain proteins in the body. There are two EGF receptors, ErbB-1 and HER-1. These receptors are manipulated to slow down or inhibit cell growth as well as induce cellular apoptosis through the effect of either monoclonal antibodies or tyrosine kinase inhibitors. EGF receptors are part of the ErbB receptor family. They span the cell membrane and have three components, the extracellular domain, the transmembrane domain and the intracellular domain. The main role of EGF receptors is to control the growth of cancerous cells and initiate cell death among other functions.

EGFR Inhibitors Drugs

Below is a list of drugs that are classified as EFGR inhibitors.

  • Cetuximab (Erbitux)
  • Erlotinib (Tarceva)
  • Gefitinib (Iressa)
  • Lapatinib (Tykerb)
  • Afatinib (Gilotrif)
  • Vandetanib (Caprelsa)
  • Panitumumab (Vectibix)
  • Neratinib
  • Canertinib
  • AG-490
  • CP-724714
  • Dacomitinib
  • WZ4002
  • Sapitinib
  • Varlitinib
  • Icotinib
  • TAK-285
  • Tyrphostin 8
  • AG-18
  • Genistein
  • Chrysophanic acid
  • Butein

EGFR Inhibitors Uses

The role of the EGF receptor is inhibited through the activity of EGFR inhibitors. In this case, the binding of these tyrosine kinase inhibitors results in compromised signal transduction through the intracellular domain of tyrosine kinase. The EGFR inhibitors bind the tyrosine kinase receptors, curtailing the activity of EGF and therefore of the cancerous growth. This class of drugs is used in the treatment of different cancers, including breast, colorectal, pancreatic, renal cell, thyroid, squamous cell, head and neck, and non-small cell lung cancer among others.

EGFR Inhibitors Side Effects

A number of side effects are associated with the administration of EGFR inhibitors based on their ability to inhibit cell growth and induce apoptosis (cell death). Common side effects are listed below.

  • Upset stomach
  • Hair loss
  • Heartburn
  • Mood changes
  • Skin rash or irritation
  • Diarrhea
  • Weight loss

Contact your doctor immediately if the following side effects occur:

  • Burning or tingling in the extremities
  • Severe diarrhea
  • Severe rash
  • Painful or difficult urination
  • Chest pain
  • Severe rash

EGFR Inhibitors Interactions

EGFR inhibitors have different interactions that produce different effects. Note that not all possible interactions are listed here.

The following drugs should not be used with EGFR inhibitors:

The following drugs should be used with caution with EGFR inhibitors: