Originally manufactured by Novartis and approved by the FDA back in 1948, Cafergot is a medication prescribed for the treatment of severe vascular headaches. Vascular headaches are cluster and migraine headaches. The active ingredients in Cafergot are ergotamine tartrate and caffeine. Ergotamine tartrate is an ergot alkaloid and these act as vasoconstrictors. Cafergot acts to constrict the widened blood vessels in the lining of the brain reducing the throbbing and pain associated with the headache. Cafergot should be avoided by those with kidney disease, high blood pressure, heart disease, circulatory issues, blood vessel disorders or liver disease. Cafergot is available as rectal suppositories, tablets, and sublingual forms.