Generic Name(s): coagulation factor IX recombinant
Drug Class: Carboxylic Acids and Derivatives
Treats: hemophilia B bleeding
Benefix is a coagulation factor IX, an artificially synthesized protein that is similar to the natural protein in the body, which helps in blood clotting. This man-made protein is produced using recombinant technology. It is a synthetic protein that takes the form of factor IX in body. Benefix helps in controlling, treating, or preventing the bleeding that is associated with hemophilia B. This medication may be used to control bleeding among patients with hemophilia B who are undergoing surgery.
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This drug is administered in people with deficiency or inadequacy of coagulation factor IX. Benefix works to replace factor IX in order to enable blood to clot properly. It is therefore, used to control as well as treat and prevent the bleeding, which is witnessed in people with hemophilia B. People with Hemophilia B, also referred to as Christmas disease or factor IX deficiency, have problems with blood clotting. Since they do not have adequate of the blood protein (factor IX) responsible for clotting of blood, they are likely to experience problems of excessive bleeding whenever they sustain an injury or are operated on.
- Factor IX Deficiency
- Hemophilia B
The dose and the duration of the therapy is determined by the severity of the factor IX deficiency, the clinical condition of the patient, and the location as well as extent of bleeding. The following Benefix dosage is an average dose and could differ among individuals. Follow your medical professional's directions carefully for best results.
- Early hemorrhage: About 20 to 40 International units/kg of Benefix is used for one day or until bleeding is resolved
- Extensive hemorrhage: 30 to 60 International units/kg is administered for 3 to 4 days or until the pain is resolved
- Life-threatening: 60 to 1hemorrhage00 International units/kg is given in every 8 to 24 hours until the risk is resolved
- Minor surgery: 30 to 60 International units/kg is administered at least one day or until healing
- Major surgery: 80 to 100 International units/kg is given to a patient in every 8 to 24 hours until the wound heals.
Benefix Side Effects
When Benefix is administered, patients may experience side effects some of which may be serious. It is not uncommon to have side effects. If you experience any severe side effects, consult with your doctor or medical professional immediately. Below is a list of known side effects. Note that this list is not a complete list of side effects.
- Warmth and redness
- Tingly feeling under skin
- Pain and swelling in body part where the drug was injected
Contact your doctor immediately if you experience the following:
- Feeling like passing out
- Chills or fever
- Sudden headache
- Problems with vision, balance, or speech
- Swelling of ankles or feet
- Loss of appetite
- Weight gain
- Continued bleeding even after the treatment
Coagulation factor IX recombinant increases the effects caused by the drug human prothrombin complex by adding drug effect. If you take these drugs together, you may have increased risks of developing blood clots in body. Benefix should not be used together with drugs that aid in clotting such tranexamic acid.