Brand Name(s): Colazal
Drug Class: 5-aminosalicylates
Treats: Ulcerative colitis
Balsalazide is the generic name of Colazal. The drug belongs to a group of medicines known as 5-aminosalicylates. Moreover, it is packed and sold in capsules each which contains 750 mg of Balsalazide disodium-the active ingredient in Colazal. Besides the main ingredient above, there are numerous other inactive ingredients like magnesium stearate.
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Balsalazide is an anti-inflammatory drug applied in the treatment of the inflammatory bowel disease commonly known as Ulcerative Colitis. Other drugs can be used to treat the same condition as well but colazal is usually preferred over the others since it is able to deliver the active agent beyond the small intestine to the large intestine which is the active site of ulcerative colitis. Again, this drug helps in eradication of all forms of inflammations ranging from mild to moderate. Up until now, the mechanism of working of this drug is not yet known but speculations are that it reduces inflammation of the colon thereby preventing the production of substances that facilitate inflammation.
- Ulcerative Colitis
Since Balsalazide is used in the treatment of somehow specific conditions, the drug dosage guidelines are also relatively specific. However, a variation comes in where the drug is used to treat another condition alongside other drugs- mostly when recommended by the doctor. Some of the prescriptions for this drug are: Ulcerative-Colitis in Adults:
- For capsules, 2250 mg of Colazal is taken by mouth thrice each day for eight weeks. However, some patients may need up to 12 weeks.
- For tablets, male patients need 3.3 g administered two times a day orally for periods up to 8 weeks. On the other hands, the effectiveness of this drug on female patients is yet to be established.
Active Ulcerative-Colitis in Children:
- For mild to moderately active colitis, and in children five years and above, 2250 mg capsule is administered by mouth thrice per day, or 750 mg can be given three times each day for eight weeks.
- However, the medical expert involved can decide to adjust the dosage according to their preference and the prevailing condition of the patient.
Balsalazide Side Effects
Just like any other drug, Balsalazide may or may not reveal its side effects to the patients. It is paramount for the patient to use the drug while strictly following each instruction to the letter; this will help them avoid side effects which arise from negligence. Here are some of the side effects of Balsalazide.
- Bladder pain
- Bloody diarrhea
- bloody or cloudy urine
- bloody stools
- difficult, burning, or painful urination
- frequent urge to urinate
- heavy bleeding
- lower back or side pain
- skin rash
Various drugs, chemicals, conditions and other substances interact with Balsalazide, it is, therefore, important for the user to have an overview of such interactions. The succeeding list below provides such an overview.