Generic Name(s): Antihemophilic Factor (Recombinant)
Drug Class: Anticoagulant
Treats: Hemophilia A, Bleeding
Advate is a medicine used in the treatment of bleeding disorders in those suffering from hemophilia. The active pharmaceutical ingredient of the medicine is antihemophilic factor, a factor that promotes the clotting process in these patients. It is also used as a prophylaxis against bleeding in hemophilic patients prior to dental work or surgical operations. Common side effects of the medicine include flu-like symptoms, nausea, weakness and swelling, particularly at the point where the injection is administered. Currently, there are no known drug interactions that occur with Advate.
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Advate is used in the treatment of the following conditions, bleeding episodes, hemophilia A and ,prophylaxis of bleeding. This drug may be used for purposes not mentioned here, as determined by your doctor. Advate is part of the coagulation factors drug class.
- Hemophilia A
It's worth noting that the following doses are not fixed and, instead, depend on the nature of the complaint, its severity, and whether the patient has any complicating factors such as disease or co-administration of other interacting drugs. However, the following values are considered the typical dose of Advate.
- Adults: 20-40 IU/dL to be maintained post-infusion. Further infusions take place every twelve or twenty-four hours thereafter, usually between 10-20 IU/kg.
- Adults: 30-60 IU/dL to be maintained post-infusion. Further infusions take place every twelve or twenty-four hours thereafter, usually between 15-30 IU/kg.
- Adults: 60-120 IU/dL to be maintained post-infusion. Further infusions take place every twelve or twenty-four hours thereafter, usually between 30-50 IU/kg.
Control of Minor Bleeding
Control of Moderate Bleeding
Control of Severe Bleeding
Advate Side Effects
The most common side effects while taking Advate are listed below, but this is by no means an exhaustive list of adverse effects. The majority of patients do, however, experience little to no effects, but a very small proportion of patients can experience hypersensitivity reactions. If you are worried about any side effects or what will occur on taking this medication, you should discuss this with your healthcare provider. Consult your doctor should you experience any of the following symptoms while taking Advate.
- Fever Flu-like symptoms
- Bone pain
- Irregular heartbeat
- Difficulty breathing
- Skin rash
There are no known interactions with Advate. However, consult with your doctor before starting this medication. A doctor or medical professional will be able to provide a list of interactions with Advate to ensure no serious side effects occur.